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Oxygen! 'More or Less' - The Benefits explained

Summary of "Therapeutic Intermittent Hypoxia with a Hyperoxic 'Chaser'


  • Intermittent Hypoxic Training (IHT) is gaining traction across various medical fields, particularly in sports performance and wellness.

  • IHT involves exposing individuals to short periods of low oxygen (hypoxia), followed by periods of normal or high oxygen (hyperoxia), to stimulate physiological adaptations.

Science and Physiology

  • IHT stimulates Hypoxia Inducible Factor-1 (HIF-1), a key regulator in cellular response to low oxygen conditions, affecting over 100 genes.

  • HIF-1 activation leads to several beneficial physiological responses, including increased production of erythropoietin (EPO) and other growth factors, enhanced angiogenesis, and improved glucose metabolism.

Practical Application

  • IHT is practiced using specialised equipment that can vary oxygen levels, allowing safe administration of hypoxia and hyperoxia.

  • Commonly used in sports to enhance performance, IHT is also being explored for therapeutic potential in conditions like cardiovascular diseases, diabetes, and obesity.

Supporting Evidence

  1. Altitude Training Benefits: Demonstrated improvements in oxygen transport and VO2max among athletes.

  2. Molecular Adaptations: Hypoxic conditions enhance muscle oxygen delivery and efficiency through increased vasodilation and mitochondrial adaptations.

  3. Clinical Applications: Research indicates potential benefits in metabolic syndrome, cognitive function, and overall well-being.

  4. Safety and Efficacy: Studies support the safety of controlled IHT, with benefits outweighing risks when properly administered.

  5. Combination Therapies: Integrating IHT with other treatments like cryotherapy or hyperbaric oxygen therapy could enhance therapeutic outcomes.

  6. Innovative Equipment: Development of advanced hypoxia-inducing machines allows for precise oxygen level adjustments, improving safety and effectiveness.

  7. Physiological Mechanisms: IHT stimulates protective responses in the body, such as antioxidant enzyme production and growth factor release.

  8. Hormesis Effect: Optimal health benefits observed with moderate, intermittent hypoxic exposures as opposed to continuous or severe hypoxia.

  9. Population Studies: Observations from high-altitude dwellers suggest long-term health benefits of natural hypoxic exposure.

  10. Emerging Research: Ongoing studies continue to explore the broad potential of IHT in both athletic and medical settings.


Intermittent Hypoxic Training, especially when combined with a hyperoxic "chaser", represents a promising approach in both therapeutic and performance-enhancing settings. It leverages natural adaptive mechanisms to potentially improve a variety of health outcomes. Proper equipment and protocols are critical to maximising benefits and minimising risks.

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